| Year |
Event |
| 338 BC | Macedonia, under Philip of Macedonia conquers Greece at the Battle of Chaeronea. |
| 336-323 BC | Reign of Alexander the Greatas king of Macedonia and conqueror of Persia. |
| 335 BC |
Alexander destroys Thebes. |
| 334 BC |
Alexander invades Persia. Battle of the Granicus delivers Asia Minor. |
| 333 BC |
Alexander cuts Gordian Knot; Victory at Battle of Issus delivers Syria. |
| 332 BC |
Siege of Tyre ends in a hard-won victory for the Macedonians; Egypt opens its doors to Alexander. |
| 331 BC | Alexander meets Darius III in Battle of Arbela—conquers all of Persia. |
| 327 BC |
Alexander invades central Asia and conquers India at the Battle of Hydaspes. |
| 323 BC |
Death of Alexander, and the division of his Empire. |
| 322 BC | Death of Demosthenesthe orator. |
| 302 BC |
Division of Alexander's empire among his Generals settled at the Battle of Ipsus. |
| 280 BC |
The Achaean League of city-states on the Peloponnese instituted. |
| 280 BC | Pyrrhus, King of Epirus defeats the Romans at the Battle of Heraclea, but is eventually driven from Italy. |
| 183 BC | Achaean League under Philopoemen defeats the tyrant of Sparta. |
| 168 BC |
Romans conquer Macedonia at the Battle of Pydna. |
| 146 BC |
The Achaean League resists Roman domination and is defeated. The Romans destroy Corinth. |